Oral supplementation of vitamin E is recommended in many skins’ therapies, such as: yellow nail syndrome, epidermolysis bullosa, cutaneous ulcers, pressure ulcers and burns, sub corneal pustular dermatosis, scleroderma, morphea, calcinosis cutis, Raynaud’s phenomenon, and inflammatory diseases. Some studies suggest that a poor diet of vitamin E could be related with skin disorders. Topical applications are designed for treating melasma, protecting against ultraviolet radiation (UVR) and improving aging damages, The association of vitamin E with other antioxidants increase the effects in skin. However, the conversion to the purified (isolated) form is required in skin to obtain the desired effects. It is a classic dermatological ingredient used alone in its purified form, alpha-tocopherol or by its derivatives. Alpha-tocopherol is the main agent capable of removing peroxyl radicals from lipid membranes, such as membranes or low-density lipoproteins (LDL). The free radical scavenging reaction occurs through the formation of a stable, low-energy radical, tocopheroxyl, which does not have the capacity to react with the free radical-forming agent. ) and singlet oxygen ( 1O 2), which favors lipid peroxidation.The antioxidant activity of vitamin E (alpha-tocopherol) has its property due to its ability to react mainly with the peroxyl radical (HOH The antioxidant activity of vitamin E is directly linked to its ability to inhibit the lipid peroxidation in unsaturated fatty acids, incorporating itself into cell membranes, which effectively inhibits lipid peroxidation. Vitamin E can eliminate free radicals induced by endogenous and/or exogenous agents such as ultraviolet radiation, drugs and pollution agents, avoiding their deleterious effects. Vitamin E is the most well-known fat-soluble non-enzymatic antioxidant, mainly for its ability to inhibit the activity of pro-oxidant agents generated by reactive oxygen species (ROS).
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